双相情感障碍的认知子组:与来自大脑的神经营养因子和C反应性蛋白的关联
Ahmet Mete Demir1,2, Yasemin Görgülü2, Kübra Söğüt2
1Liaison Psychiatry, Derbyshire Healthcare NHS Foundation Trust, Chesterfield Royal Hospital, Chesterfield, UK.
BJPsych open
|December 10, 2025
概括
双极性障碍患者表现出与大脑衍生神经营养因子 (BDNF) 和C反应蛋白 (CRP) 水平相关的独特认知子组. 较高的CRP表明总体损伤,而BDNF可能与特定的缺陷有关,表明炎症和神经可塑性的作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物化学 生物化学
背景情况:
- 双相情感障碍中的认知障碍呈现出显著的异质性.
- 了解认知子组及其生物学基础对于改善管理至关重要.
- 大脑衍生神经营养因子 (BDNF) 和C反应蛋白 (CRP) 分别与神经可塑性和炎症有关.
研究的目的:
- 在双相情感障碍患者群体中识别不同的认知子组.
- 检查这些认知子组与BDNF和CRP的血清水平之间的关联.
主要方法:
- 一项涉及149名双相情感障碍患者和48名健康对照者的横截面研究.
- 综合的神经心理测试电池来评估认知功能.
- 集群分析用于分组识别,区分功能分析用于验证,以及血清BDNF/CRP水平测量.
主要成果:
- 确定了三个认知子组:完整的认知,选择性认知障碍 (SIC) 和全球认知障碍 (GIC).
- SIC组显示BDNF水平升高;GIC组显示CRP水平升高.
- 在CRP和整体认知表现之间发现了负相关性;BDNF与口语流性,短期和工作记忆负相关. CRP>4.3 mg/L预测的全球损伤.
结论:
- 双相情感障碍的认知障碍可以分为与BDNF和CRP水平相关的不同子组.
- 这些发现突出了炎症 (CRP) 和神经可塑性 (BDNF) 在双相情感障碍认知衰退中的作用.
- BDNF和CRP可以作为潜在的生物标志物,用于识别患有严重认知障碍风险的患者.
相关概念视频
01:30Bipolar Disorder
591
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
591
01:29Biological Causes of Schizophrenia
464
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
464
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
518
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
518
01:18Depression: Overview
747
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
747