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在PGPR中代谢重编程揭示了交叉养驱动的生理变化和代谢适应

Kamogelo Mmotla^1,2, Farhahna Allie¹, Thendo Mafuna¹

¹Faculty of Science, Department of Biochemistry, University of Johannesburg, Johannesburg, South Africa.

Frontiers in microbiology

|December 10, 2025

概括

在Priestia megaterium和Bacillus licheniformis之间的代谢交叉养驱动了适应性相互作用. 了解这些促进植物生长的根茎细菌 (PGPR) 的代谢交换,可以为提高土壤健康的生物肥料设计提供信息.

科学领域:

微生物生态学微生物生态学
代谢学代谢学代谢学
植物与微生物的相互作用

背景情况:

草圈微生物相互作用对土壤健康和植物生长至关重要.
代谢交叉养显著塑造微生物社区的结构和功能.
促进植物生长的草原细菌 (PGPR) 使用交叉养来适应.

研究的目的:

为了研究Priestia megaterium和Bacillus licheniformis之间的代谢相互作用.
了解代谢物交换如何影响细菌生长和代谢重编程.
阐明在营养有限的环境中适应性相互作用的机制.

主要方法:

使用了UPLC-MS的整合性代谢学方法.
分析了不同生长阶段的个体和共同培养的细胞外代谢物.
采用分子网络和多变量统计分析用于代谢物识别和途径丰富 (KEGG,MetaboAnalyst).

主要成果:

在P. megaterium和B. licheniformis之间进行的相互代谢物交换引起了明显的代谢转变.
B. licheniformis的代谢物抑制了P. megaterium的生长,而P. megaterium的代谢物刺激了B. licheniformis的生长.
鉴定出氨酸,氨酸和氨酸生物合成途径是调解这些相互作用的中心枢纽,影响合作或竞争动态.

结论:

在营养限制下,代谢物交叉养驱动了PGPR中的代谢重编程和适应性相互作用.
这些发现为设计微生物联盟和优化生物肥料提供了机制基础.
未来的多学科研究将进一步阐明可持续生物技术创新的遗传和监管决定因素.

关键词:

细菌类形状is.普里斯蒂亚巨动物群 (Priestia megaterium) 是一个巨动物群.可持续发展目标 (SDGs) 是一个可持续发展目标.交叉养 - 交叉养是什么?代谢生物组的代谢生物组促进植物生长的树枝细菌

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