夜间高血压预测了患有初级高血压的儿童的左心室缩
Jiayu Wang1,2, Jialing Zhang1,2, Chen Chu3
1National Health Commission Key Laboratory of Neonatal Diseases (Fudan University), Shanghai, China.
Translational pediatrics
|December 10, 2025
概括
夜间高血压是患有初级高血压的儿童左心室缩 (LVH) 的关键危险因素. 结合夜间高血压的新预测模型显示,早期LVH识别的准确性中等.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 高血压研究 高血压研究
- 心血管成像 - 心血管成像
背景情况:
- 儿童高血压是一个日益严重的全球健康问题.
- 左心室缩 (LVH) 是儿科高血压中最常见的目标器官损伤.
- 关于中国儿童的LVH危险因素的数据有限.
研究的目的:
- 在患有初级高血压的儿童中识别LVH的危险因素.
- 在这个人群中开发和验证LVH的预测模型.
- 为了解决来自中国儿科队伍的证据稀缺问题.
主要方法:
- 一项横截面研究包括121名高血压儿童 (3-17岁).
- 收集的数据包括临床参数,实验室结果,24小时门诊血压监测 (ABPM) 和心声回声.
- 使用后勤回归识别了风险因素,并使用ROC曲线和适合性测试构建和评估了一个预测模型.
主要成果:
- 在17.4%的参与者中,LVH存在,主要以同心缩的形式.
- 夜间高血压成为LVH的重要独立风险因素 (OR=4.07).
- 一个预测模型 (年龄,性别,BMI,夜间高血压) 显示了中度的歧视 (AUC=0.710) 和良好的校准.
结论:
- 夜间高血压是儿科初级高血压中LVH的一个关键的独立风险因素.
- 开发的预测模型为儿童早期LVH风险评估提供了潜力.
- 进一步的研究可以完善这个模型,用于儿科高血压管理的临床应用.
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