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糖尿病与周围之间的关联:一个元分析.

Hui Zhang1, Xiang Gao1, Yuanming Qu2

  • 1Graduate School of Clinical Medical College of Traditional Chinese Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, People's Republic of China.

Diabetes, metabolic syndrome and obesity : targets and therapy
|December 10, 2025
PubMed
概括

糖尿病 (DM) 显著增加了近腹 (PA) 的风险,具有双向联系和独特的临床形状. 男性性别,特定的微生物变化和更高的复发率与DM和PA有关.

关键词:
直肠感染 直肠感染伴随性疾病发生率.基于证据的医学是基于证据的医学.过高血糖症 (hyperglycemia) 是一种疾病.

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科学领域:

  • 胃肠病学和肝病学 胃肠学和肝病学
  • 内分泌学 在内分泌学.
  • 传染性疾病 传染性疾病

背景情况:

  • 周围 (PA) 是一种常见的直肠紧急情况,影响全球人口的2-3%.
  • 越来越多的证据将PA与代谢障碍联系在一起,特别是糖尿病 (DM).
  • 预计到2045年DM案件的增长预计将达到10亿,这强调了需要了解DM-PA协会的必要性.

研究的目的:

  • 调查DM和PA之间的双向流行病学关系.
  • 确定在患有和没有DM的患者中PA的独特临床特征.
  • 为改善PA和DM风险分层和管理策略做出贡献.

主要方法:

  • 从主要数据库 (PubMed,EMBASE等) 系统地检索DM和PA的观察性研究. 在2024年11月之前.
  • 独立的研究选择,数据提取和使用纽卡斯尔-太华尺度进行质量评估.
  • 使用随机效应模型进行元分析,以计算聚合流行率,OR,RR和CI,并进行异质性和偏差评估.

主要成果:

  • 发现了强烈的双向关联:30.7%的PA病例发生在DM患者中,22.0%的DM患者患上了PA.
  • 在DM患者中,男性显著增加了PA风险 (OR=15.00).
  • 糖尿病与肠道微生物群的改变有关 (肠道大肠杆菌减少,肺炎克莱布西拉增加),的增加,早期发病和复发的增加.

结论:

  • DM和PA表现出相互风险放大和独特的临床特征,包括性别特定的脆弱性和微生物转移.
  • 患有DM的患者呈现出明显的PA表现和更差的预后结果.
  • 个性化抗微生物策略和加强术后监测对于患有PA的DM患者至关重要.