糖尿病与周围之间的关联:一个元分析
Hui Zhang1, Xiang Gao1, Yuanming Qu2
1Graduate School of Clinical Medical College of Traditional Chinese Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|December 10, 2025
概括
糖尿病 (DM) 显著增加了近腹 (PA) 的风险,具有双向联系和独特的临床形状. 男性性别,特定的微生物变化和更高的复发率与DM和PA有关.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
背景情况:
- 周围 (PA) 是一种常见的直肠紧急情况,影响全球人口的2-3%.
- 越来越多的证据将PA与代谢障碍联系在一起,特别是糖尿病 (DM).
- 预计到2045年DM案件的增长预计将达到10亿,这强调了需要了解DM-PA协会的必要性.
研究的目的:
- 调查DM和PA之间的双向流行病学关系.
- 确定在患有和没有DM的患者中PA的独特临床特征.
- 为改善PA和DM风险分层和管理策略做出贡献.
主要方法:
- 从主要数据库 (PubMed,EMBASE等) 系统地检索DM和PA的观察性研究. 在2024年11月之前.
- 独立的研究选择,数据提取和使用纽卡斯尔-太华尺度进行质量评估.
- 使用随机效应模型进行元分析,以计算聚合流行率,OR,RR和CI,并进行异质性和偏差评估.
主要成果:
- 发现了强烈的双向关联:30.7%的PA病例发生在DM患者中,22.0%的DM患者患上了PA.
- 在DM患者中,男性显著增加了PA风险 (OR=15.00).
- 糖尿病与肠道微生物群的改变有关 (肠道大肠杆菌减少,肺炎克莱布西拉增加),的增加,早期发病和复发的增加.
结论:
- DM和PA表现出相互风险放大和独特的临床特征,包括性别特定的脆弱性和微生物转移.
- 患有DM的患者呈现出明显的PA表现和更差的预后结果.
- 个性化抗微生物策略和加强术后监测对于患有PA的DM患者至关重要.
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