对非小细胞肺癌的病理反应进行叙述性回顾:挑战,影响和未来方向
Yuan Li1, Fei Liang2, Suijun Xiao3
1Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
Translational lung cancer research
|December 10, 2025
概括
在非小细胞肺癌 (NSCLC) 中评估病理反应对于新辅助疗法至关重要. 目前的方法在标准化和解释方面面临挑战,影响了可切除NSCLC的治疗决策.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 翻译研究是翻译研究.
背景情况:
- 新辅助疗法越来越多地用于非小细胞肺癌 (NSCLC).
- 病理反应是一个关键的治疗终点,但面临评估挑战.
- 病理反应的标准化和解释对于治疗疗效至关重要.
研究的目的:
- 审查目前在评估NSCLC病理反应的方法和挑战.
- 总结评估技术,生物标志物和新辅助治疗的数据.
- 探索NSCLC病理反应和生存结果之间的关联.
主要方法:
- 对NSCLC病理评估指南和挑战的文章的系统审查.
- 包括报告新辅助治疗病理反应的研究.
- 提取的关于病理反应和生存的数据的描述性总结.
主要成果:
- 目前用于评估可切除NSCLC病理反应的方法存在局限性.
- 评估的变化,技术/生物标志物的有限标准化,以及解释困难仍然存在.
- 审查了对各种新辅助疗法 (化疗,放射,免疫,TKI,抗血管原药) 的病理反应和生存关联的数据.
结论:
- 病理反应是NSCLC治疗疗效的有价值的早期指标.
- 目前的局限性要求对治疗决策采取平衡的方法.
- 考虑长期生存和生活质量与病理反应一起是必不可少的.
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