在抗血管内皮生长因子静脉内注射后,莫亚莫亚病的加速
Abdulaziz K Alotaibi1, Sameeha Fallatah1, Nabeel Refka1
1King Abdullah International Medical Research Center and King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
概括
抗血管内皮生长因子 (VEGF) 药物可能会恶化莫亚莫亚病 (MMD) 的进展. 这份案例报告表明,抗VEGF治疗可能会阻碍MMD患者的关键附带血管形成.
科学领域:
- 神经学 神经学
- 眼科医生 眼科 眼科
- 血管生物学 血管生物学
背景情况:
- 莫亚莫亚病 (MMD) 是一种罕见的,渐进的脑血管疾病,其特征是脑动脉封闭和补偿附带血管形成.
- 血管内皮生长因子 (VEGF) 在血管生成中发挥作用,可能影响MMD的发病性.
- 抗VEGF疗法在眼科中使用,通过抑制新血管化来治疗糖尿病视网膜病变等疾病.
研究的目的:
- 报告抗VEGF治疗后可能出现Moyamoya疾病进展的病例.
- 调查抗VEGF药物可能对MMD中附带血管发展产生负面影响的假设.
主要方法:
- 一个55岁的男性患有糖尿病视网膜病变,接受了抗VEGF药物治疗的病例报告.
- 临床表现和神经成像分析用于莫亚莫亚病的进展.
- 对抗VEGF治疗与MMD病理生理学之间的潜在相互作用的审查.
主要成果:
- 患者在接受抗VEGF注射后出现了与莫亚莫亚进展一致的症状.
- 神经成像证实了血管封闭性疾病的进展.
- 患者经历了神经缺陷,包括面部和身体的虚弱,消化不良和脱节症.
结论:
- 抗VEGF治疗可能有助于莫亚莫亚病的进展.
- 需要进一步的研究,以了解抗VEGF药物与MMD中大脑附带循环之间的相互作用.
- 这一案例突出显示了与抗VEGF药物在患有或有Moyamoya疾病风险的患者中使用相关的潜在阴性风险.
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