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Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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人类瘤中的BAG3

Paola Manzo1, Anna Lisa Cammarota1, Jelena Dimitrov1

  • 1Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.

Frontiers in oncology
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PubMed
概括

蛋白质BAG3 (Bcl-2-关联的乙基-3) 在许多癌症中表达和分泌很高,这表明它在瘤存活中的作用. 患者血清中BAG3水平升高可能表明肝,胰腺或卵巢癌.

关键词:
BAG3 BAG3 BAG3 BAG3 BAG3 BAG3 BAG3 BAG3 BAG3 BAG3生物标志物生物标志物癌症细胞系是癌症细胞系中的一个.人类血清的人类血清瘤是一个瘤.

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科学领域:

  • 在瘤学瘤学.
  • 分子生物学分子生物学
  • 生物化学 生物化学

背景情况:

  • 蛋白质BAG3 (Bcl-2-关联的阿坦基因3) 被认为是参与各种癌症类型中细胞存活的压力诱导因素.
  • 它在各种恶性瘤中的精确作用和表达模式需要进一步阐明.

研究的目的:

  • 在广泛的癌症细胞系和原发性瘤中研究BAG3的表达和分泌.
  • 评估BAG3作为潜在的诊断生物标志物和瘤学治疗点.

主要方法:

  • 对来自十种不同癌症类型的24种癌细胞系中BAG3表达和分泌的分析.
  • 细胞BAG3度与癌症患者和健康对照者的血清BAG3度的比较.
  • 在初级瘤样本中对BAG3表达的免疫组织化学评估,与瘤等级相关.

主要成果:

  • 在所有分析的癌细胞系中,BAG3表现出无处不在的表达和分泌.
  • 与健康个体相比,被诊断患有肝,胰腺和卵巢癌的患者的血清BAG3水平显著升高.
  • 在多种瘤类型中证实了广泛的高BAG3表达,经常与较高的瘤等级相关.

结论:

  • BAG3是瘤细胞存活的关键调节剂,在各种癌症中始终表达和分泌.
  • 血清BAG3水平升高显示为特定癌症类型的潜在生物标志物,包括肝癌,胰腺癌和卵巢癌.
  • BAG3代表了癌症治疗策略的一个有前途的治疗标.