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Updated: Jan 9, 2026

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代代谢物R-2-基酸盐通过FTO/NF-κB通路抑制微质激活

Lu Wang1, Huiting Zhang1, Xifeng Jing1

  • 1Hematology Center, Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematological Diseases, Soochow University, Suzhou, China.

Frontiers in oncology
|December 10, 2025
PubMed
概括

突变IDH1产生R-2HG,它通过抑制FTO/NF-κB通路来抑制微质IL-6的产生. 这一发现揭示了R-2HG在调节质瘤免疫微环境中的新机制.

关键词:
在 FTO FTO FTO.在 NF-κBB 中.在R-2HG中使用.质瘤 质瘤 是一种微质细胞中的微质细胞

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