口腔微生物群及其对炎症性肠病的影响:文学综述
Xiao-Kai Chen1, Tao Mao1, Xiang Song1
1Department of Gastroenterology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, People's Republic of China.
International journal of general medicine
|December 10, 2025
概括
以前被忽视的口腔微生物群在炎症性肠病 (IBD) 发病过程中发挥着重要作用. 了解这种口肠轴对于IBD治疗策略至关重要.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),涉及慢性肠道炎症.
- 肠道炎症的发病因是宿主基因和微生物群落之间的复杂相互作用.
- 肠道微生物群在IBD中的作用已经确立,但口腔微生物群的贡献是一个新兴的研究领域.
研究的目的:
- 审查口腔微生物群在炎症性肠病 (IBD) 发病过程中的新兴作用.
- 综合了解IBD口腔肠轴的最新进展.
- 突出口腔微生物转移对肠道炎症的潜在影响.
主要方法:
- 对口腔微生物群和IBD当前研究的文献综述.
- 关于微生物从口腔转移到肠道的综合证据.
- 分析肠道环境中口腔微生物触发的免疫反应.
主要成果:
- 口腔微生物可以通过唾液转移到肠道.
- 口腔细菌和炎症细胞可以从口腔迁移到肠道.
- 这种转位可以触发过度的宿主免疫反应,从而导致IBD的进展.
结论:
- 口腔微生物群是IBD病原发生的一个被低估的因素.
- 口腔微生物平衡的破坏可能会影响肠道炎症.
- 对口腔肠轴的进一步研究对于新的IBD治疗方法至关重要.
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