解读癌症中的代谢功能障碍:早期检测和个性化治疗的基础
Pradeep M K Nair1, Ayyappan Palanisamy1, Sekar Sivaranjani1
1Department of Integrative Oncology, Mirakle Integrated Health Centre, Pollachi, India.
Frontiers in endocrinology
|December 10, 2025
概括
代谢功能障碍,不仅仅是遗传,可能是癌症的前身. 关键的代谢标志物可以帮助预测癌症风险,并指导早期干预以获得更好的结果.
科学领域:
- 综合性瘤学 综合性瘤学
- 癌症生物学 癌症生物学
- 代谢医学是一种代谢医学.
背景情况:
- 癌症的全球负担需要新的预防和检测策略.
- 新出现的证据表明代谢功能障碍是癌症的前体,超出了传统的遗传重点.
- 代谢变化,如葡萄糖,氨基酸和脂质代谢中断,通过氧化应激和免疫逃避,有助于癌症的发展.
研究的目的:
- 探索代谢功能障碍在癌症发展中的作用.
- 确定关键的代谢标志物作为癌症风险的潜在早期指标.
- 讨论代谢标记在综合性瘤学中的有用性,用于预测和预后.
主要方法:
- 关于癌症代谢途径的科学文献的综述.
- 讨论特定的代谢标记物,包括类固醇,乳酸脱酶 (LDH),HbA1c,胰岛素,皮质醇,中性粒细胞与淋巴细胞的比率 (NLR),C反应蛋白 (CRP),维生素B12,甲状腺激素 (PTH),电离,雌激素和孕激素.
- 整合综合性瘤实践的见解.
主要成果:
- 代谢标记物,如同类半素,LDH,HbA1c,胰岛素,皮质醇,NLR,CRP,维生素B12,PTH,电离,雌激素和孕激素显示出早期癌症风险指标的潜力.
- 这些标记物,当被认为是集体的,突出相互连接的生化途径促进瘤发生.
- 代谢标记可以作为预测和预后工具,补充遗传和成像诊断.
结论:
- 代谢功能障碍是癌症发展和进展的关键因素.
- 早期识别和监测代谢标记可以及时进行干预,以减轻癌症风险.
- 需要进一步的多中心数据来验证这些代谢标记物的转化效用在不同的临床环境中.
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