阻塞性睡眠呼吸暂停和糖尿病病之间的双向关联:系统性审查和元分析
Jieyu Zhang1, Yuandong Li1, Bo Dai1
1Changchun University of Chinese Medicine, Changchun, China.
Frontiers in endocrinology
|December 10, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 显著增加糖尿病病 (DKD) 的风险,并且DKD与更严重的OSA有关. 在糖尿病患者中早期查OSA以及在OSA患者中对脏进行监测至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肺部病理学 肺部病理学
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病病 (DKD) 是糖尿病的一个主要并发症.
- 阻塞性睡眠呼吸暂停 (OSA) 在糖尿病患者中很常见,可能会影响功能.
- 需要进一步调查OSA和DKD之间的双向关系.
研究的目的:
- 系统地审查和元分析OSA和DKD之间的关联.
- 探索OSA对DKD风险和进展的影响.
- 为了检查在DKD患者中OSA的流行率.
主要方法:
- 系统的文献搜索数据库,包括科克兰图书馆,PubMed,Embase和科学网络.
- 对14项涉及5316名参与者的研究进行了元分析.
- 使用纽卡斯尔-太华尺度评估研究质量,使用GRADE评估证据确定性.
主要成果:
- 患有OSA的患者患DKD的风险增加了1.92倍.
- 与轻度至中度OSA (OR = 1.52) 相比,严重的OSA与DKD的风险更高 (OR = 2.29) 相联系.
- OSA患者表现出较低的eGFR,而DKD患者显示出较高的AHI和较低的平均血氧和度.
结论:
- 在OSA和DKD之间存在着重要的双向关联.
- 这些发现强调了在糖尿病患者中进行OSA查的重要性.
- 对于患有OSA的人来说,建议定期监测功能.
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