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Updated: Jan 9, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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瘤不可知疗法:一种潜在的治疗方法,用于SMARCA4缺乏的恶性瘤

Yang Liu1, Zhi-Hui Liu1, Qiong Zhang1

  • 1Department of Clinical Oncology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Therapeutic advances in medical oncology
|December 10, 2025
PubMed
概括

缺少SMARCA4驱动了对标准治疗有抗性的侵袭性癌症. 新型瘤不可知疗法,包括免疫检查点抑制剂和合成致命性策略,对SMARCA4缺乏的瘤显示有前途.

关键词:
在SMARCA4缺乏的瘤中.表观遗传调节 表观遗传调节免疫检查点抑制剂免疫检查点抑制剂合成杀伤性 合成杀伤性瘤无知疗法治疗方法

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