多基因风险,父母分居和父母关系分歧对高风险样本中青春期和年轻成年期的大量插曲性饮酒的影响
Sally I-Chun Kuo1, Vivia V McCutcheon2, Kathleen K Bucholz2
1Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey.
JAACAP open
|December 10, 2025
概括
父母分居和关系不和影响了重型偶发性饮酒 (HED) 轨迹. 遗传风险也影响了HED的过程,在欧洲裔美国人和非洲裔美国人之间观察到差异.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 发展心理学 发展心理学
背景情况:
- 父母分居和关系不和是已知与酒精使用行为相关的.
- 这些环境因素,遗传倾向和滥用酒精的轨迹之间的纵向相互作用仍然不完全理解.
- 严重的偶发性饮酒 (HED) 是一个重要的公共卫生问题,它对发育有影响.
研究的目的:
- 调查从青春期到年轻成人时期重度插曲性饮酒 (HED) 的纵向过程.
- 检查父母分居,父母关系不和,以及问题性酒精使用的多基因风险评分 (PGSPAU) 如何影响HED轨迹.
- 探索遗传倾向和不利的家庭环境之间的潜在相互作用,以塑造HED.
主要方法:
- 利用了来自"饮酒遗传学协作研究" (COGA) 未来样本的数据.
- 包括每两年评估一次的欧洲裔美国人 (EA; n=1761) 和非洲裔美国人 (AA; n=894).
- 分析了过去一年的HED频率,使用线性混合效应生长模型,考虑父母分居,不和和PGS.
主要成果:
- 在年轻成年期,HED增加,然后下降.
- 在EA中,父母分居影响了HED发病,而更高的PGSPAU预测了更快的HED增长和更慢的下降.
- 在AA中,父母关系的不和与更快的HED增长和更慢的HED衰退有关;PGSPAU没有显著影响HED过程.
结论:
- 遗传风险和父母分离/不和的暴露与HED的纵向过程有关.
- 在欧洲裔美国人和非洲裔美国人中存在这些关联的观察差异.
- 在预测HED轨迹方面,遗传风险和家长因素之间没有发现显著的相互作用.
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