相关实验视频

Updated: Jan 9, 2026

In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function
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In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function

Published on: February 27, 2019

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在3D瘤微环境中,CLL和ALL衍生的CAR T细胞之间的功能差异突出显示了CXCR4和IL-10作为潜在的调节标

Janin Dingfelder1,2,3, Michael Aigner1,2,3, Jana Lindacher1,2,3

  • 1Department of Internal Medicine 5, Hematology and Oncology Universitätsklinikum Erlangen Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.

HemaSphere
|December 10, 2025
PubMed
概括

化学抗原受体 (CAR) T细胞疗法在慢性淋巴细胞白血病 (CLL) 中由于T细胞耗尽和免疫抑制瘤微环境 (TME) 的作用,显示出有限的疗效. 针对TME的组合疗法在改善CLL中CAR T细胞功能方面表现有前途.

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Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice07:36

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