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基于发光二极管阵列的光声学计算机断层扫描 (LED-PACT) 的性能特征
Avishek Das1, Manojit Pramanik1
1Department of Electrical and Computer Engineering, Iowa State University, Ames, Iowa 50011, USA.
Biomedical optics express
|December 10, 2025
概括
一个新的,具有成本效益的发光二极管光声学计算机断层扫描 (LED-PACT) 系统提供了与激光系统相比较的成像性能. 这项创新有望为更广泛的临床应用提供便携式光声学成像.
科学领域:
- 生物医学光学 生物医学光学
- 医疗成像医学成像
- 声学成像 声学成像
背景情况:
- 光声学计算机断层扫描 (PACT) 通常依赖于昂贵的脉冲激光二极管 (PLD).
- 需要更具成本效益和便携性的PACT系统,以实现更广泛的临床采用.
- 为PACT开发替代光源对于推动该领域的发展至关重要.
研究的目的:
- 开发和评估一种新的,成本效益高的基于发光二极管的PACT (LED-PACT) 系统.
- 将LED-PACT系统的成像性能与传统的基于PLD的PACT进行比较.
- 评估在PACT应用中使用定制纳秒脉冲LED阵列的可行性.
主要方法:
- 集成37LED定制纳秒脉冲LED阵列 (850nm,100ns脉冲宽度) 与单元超声传感器进行循环扫描.
- 使用自制纳米秒脉冲电流源 (NSPCS) 驱动器驱动LED阵列.
- 使用幻影和组织研究进行性能评估,将成像深度,分辨率和信号噪声比率 (SNR) 与PLD-PACT进行比较.
主要成果:
- 该LED-PACT系统实现了22.4dB (2.25MHz UST) 的SNR和178μm (5MHz UST) 的空间分辨率.
- 在肉组织中证明了20毫米的实际成像深度.
- 与PLD-PACT (1.88mJ) 相比,该系统在显著较低的光能 (0.18mJ) 上运行,同时保持了竞争力的性能.
- 总系统成本不到1000美元.
结论:
- 开发的 LED-PACT 系统为基于 PLD 的 PACT 提供了具有成本效益的替代方案.
- 该系统展示了具有竞争力的成像性能,包括深度,分辨率和SNR.
- 这种LED-PACT技术在开发用于临床转换的便携式和广泛可访问的光声成像设备方面具有重大潜力.
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