超越骨:重新审视维生素D在慢性肝病中的作用
Rodrigo Guerrero-Guerrero1, Osvely Mendez-Guerrero1, Anaisa Carranza-Carrasco1
1Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Distrito Federal 14080, Mexico.
World journal of hepatology
|December 10, 2025
概括
维生素D对肝脏健康至关重要,调节炎症和纤维化. 纠正维生素D缺乏症可能有利于患有慢性肝病的患者,尽管最佳补充策略需要进一步研究.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 除了代谢之外,维生素D也是肝脏健康的关键调节者.
- 活性形式,calcitriol [1α,25(OH) 2D,通过存在于各种肝细胞中的维生素D受体 (VDR) 起作用.
- VDR信号影响肝纤维化,炎症,氧化应激,胆酸平衡和免疫反应.
研究的目的:
- 审查维生素D缺乏和慢性肝病之间的联系.
- 探索维生素D影响肝脏病理生理学的机制.
- 讨论肝脏疾病中维生素D的临床影响和未来研究方向.
主要方法:
- 临床前和临床研究的文献综述.
- 对观察数据分析,将维生素D水平与肝病严重程度和结果联系起来.
- 检查肝细胞中维生素D-VDR信号传递的机制研究.
主要成果:
- 维生素D缺乏在慢性肝病中很普遍,例如自身免疫性肝炎,PBC,ALD,病毒性肝炎和MASLD.
- 低维生素D水平与疾病严重程度增加,并发症 (例如,SBP,sarcopenia,HE) 和死亡率相关.
- 在机械上,维生素D-VDR信号抑制纤维化,减少炎症,促进免疫耐受性,改善胰岛素敏感性.
结论:
- 维生素D在肝脏疾病的发病过程中起着重要作用.
- 纠正维生素D缺乏症对肝脏健康有潜在的治疗益处.
- 需要进一步的研究来确定患者亚组和肝病管理中维生素D补充剂的最佳剂量.
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