将脂肪肝重新定义为与代谢功能障碍相关的脂肪性肝病:对糖尿病患者的命名变更的影响
1Division of General Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States. correatl@upmc.edu.
World journal of hepatology
|December 10, 2025
概括
从NAFLD转变为MASLD更好地识别了2型糖尿病患者的肝肥胖症. 新的标准改善了诊断,并强调了对这一群体进行向治疗和查的必要性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 糖尿病是一种糖尿病.
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 命名正在演变为与代谢功能障碍相关的脂肪性肝病 (MASLD).
- 2型糖尿病 (T2DM) 经常与肝肥胖症同时发生,因此需要更新诊断框架.
- 从NAFLD过渡到MASLD的目标是更好地反映肝病的代谢驱动因素.
研究的目的:
- 探索从NAFLD更改为MASLD的命名体系背后的逻辑.
- 为了比较NAFLD和MASLD的诊断标准.
- 评估MASLD框架对T2DM肝硬化症患者的影响.
主要方法:
- 当前文献和诊断指南的小综述.
- 对NAFLD和MASLD定义的比较分析.
- 在两个框架下评估T2DM患者的患病率,特征和结果.
主要成果:
- MASLD标准涵盖了所有患有肝肥胖症的T2DM患者,强调了代谢功能障碍.
- 与NAFLD相比,MASLD在T2DM患者中发现脂肪性肝病的患病率更高.
- 在MASLD框架中考虑了双重病因,包括酒精使用,以前在NAFLD中被排除在外.
结论:
- MASLD定义增强了T2DM肝硬化患者的临床相关性和包容性.
- 挑战包括未被认可的药物诱导胆固醇炎和临床试验的重新分类需求.
- 全系统的再教育,标准化和多学科合作对于整合MASLD和改善T2DM患者的治疗结果至关重要.
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