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身体圆度指数与前列腺癌的关联:使用NHANES数据进行基于人口的横截面研究

Jianqiang Ye^1,2,3, Ang Li^1,2,3, Lili Lin^1,2,3

¹PET Center, Fujian Medical University Union Hospital, Fuzhou, China.

Translational andrology and urology

|December 10, 2025

概括

较高的身体圆度指数 (BRI) 与前列腺癌 (PCa) 风险增加有关. 与BMI等传统措施相比,BRI显示PCa风险预测得到了改进,这表明其作为一个有价值的工具的潜力.

科学领域:

在瘤学瘤学.
公共卫生公共卫生
人类测量学人类测量学.

背景情况:

前列腺癌 (PCa) 是全球癌症死亡的主要原因.
肥胖是癌症的危险因素,但传统的指标,如BMI,并不反映脂肪的分布.
身体圆度指数 (BRI) 可以更好地估计身体脂肪和内脏脂肪组织 (VAT).

研究的目的:

调查BRI和PCa在一般人群中的风险之间的关联.
将BRI的预测性能与PCa的传统人类指数进行比较.

主要方法:

对18732名美国男性 (1999-2018年NHANES) 的数据进行分析.
使用经过验证的公式计算BRI.
多变量后勤回归和受限立方线分析以评估BRI-PCa关系,调整共变量.
ROC曲线分析,将BRI与BMI,腰围和PCa歧视的体重进行比较.

主要成果:

在BRI和PCa风险之间发现了显著的正相关性.
每增加1个单位的BRI与PCa几率的17%的增加有关.
与最低四分之一相比,BRI最高四分之一的人患PCa的风险高出四倍.
与BMI,腰围和体重相比,BRI在PCa风险歧视方面表现出中度和显著的改善.

结论:

在美国一般人群中,BRI与PCa风险独立且正相关.
BRI显示出作为PCa风险评估的补充人类计量工具的潜力.
在具有临床终点的前性研究中需要进一步验证.

关键词:

身体圆性的指数 (BRI)国家健康和营养检查调查 (NHANES)前列腺癌 (PCa) 是一种癌症.内脏脂肪组织 (VAT).

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