在接受新辅助化疗治疗的乳腺癌患者中,确定最佳的Ki67截止值来预测存活率
Chun Jiang1, Tong Zhu2, Yunfei Zong3
1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Frontiers in surgery
|December 10, 2025
概括
20%的Ki67切割值有效地预测了经过新辅助化疗 (NAC) 后乳腺癌患者的生存结果. 这一发现有助于个性化预后评估,以改善患者护理和治疗策略.
科学领域:
- 在瘤学瘤学.
- 生物统计学 生物统计学
背景情况:
- 乳腺癌发病率不断上升,需要在新辅助化疗 (NAC) 后进行准确的预后.
- 基67是一个关键的预后标志物,但最佳的切断值仍在争论中.
- 这项研究旨在确定最佳的Ki67截止值,以预测NAC治疗的乳腺癌患者的存活率.
研究的目的:
- 确定乳腺癌预后的最佳Ki67切割值.
- 评估Ki67在预测NAC后无病生存 (DFS) 和整体生存 (OS) 的预后意义.
- 开发和验证用于个性化生存预测的诺莫格拉姆模型.
主要方法:
- 对255名接受NAC.治疗的乳腺癌患者的回顾性分析.
- 使用最大选择的等级统计数据来确定最佳的Ki67切断点.
- 卡普兰-梅尔生存分析,考克斯回归和LASSO用于预后变量选择.
- 构建和评估用于DFS和OS预测的nomogram模型.
主要成果:
- 20%的Ki67截止值显著差异化的生存结果.
- 高基67 (>20%) 的患者表现出较差的DFS和OS.
- Ki67是DFS和OS的独立预测器.
- 诺米图模型显示出强大的预测性能 (AUC>0.900) 和准确性.
结论:
- 20%的Ki67截止值是接受NAC的乳腺癌患者可靠的预后指标.
- 开发的整合Ki67和临床参数的诺莫格拉姆模型提供了准确的个性化预后评估.
- 这些发现支持改善乳腺癌治疗的临床决策.
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