腹膜透析相关的腹膜炎由Lautropia Mirabilis和同时发生的病毒感染引起:一个病例报告
Cunhong Deng1,2, Junjie Chen3, Jun Liu1,2
1Department of Nephrology, The Third Xiangya Hospital of Central South University, Changsha, China.
Case reports in nephrology and dialysis
|December 10, 2025
概括
奇迹性腹膜是腹膜透析患者腹膜炎的罕见原因. 这一案例突出了与细胞巨乳病毒和爱斯坦-巴尔病毒的同时感染,当培养失败时,通过下一代测序检测到.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 分子诊断学 分子诊断学
背景情况:
- 腹膜炎是腹膜透析 (PD) 的严重并发症.
- Lautropia mirabilis是一种不常见的病原体,导致PD相关的周周炎 (PDAP).
- 文化阴性PDAP带来了诊断挑战和治疗失败的风险.
研究的目的:
- 报告与L.奇迹菌,细胞大脑病毒 (CMV) 和爱斯坦-巴尔病毒 (EBV) 共同感染引起的PDAP的第一个病例.
- 评估针对性下一代测序 (tNGS) 在诊断耐火,培养负的PDAP中的实用性.
主要方法:
- 一名患有末期病的患者在PD上呈现了复发的PDAP.
- 腹腔透析废液 (PDE) 培养物最初对L.mirabilis.呈阴性结果.
- 针对性下一代测序 (tNGS) 在PDE上进行.
主要成果:
- 在患者的PDE中,tNGS检测到L.奇迹菌,CMV和EBV.
- 结合抗生素和抗病毒疗法导致PDAP的快速临床改善和解决.
- 患者完全康复,在PDE中白细胞数量正常.
结论:
- 传统培养可能会错过像L. mirabilis.这样的罕见病原体.
- tNGS可以成为诊断培养负PDAP的一个有价值的工具.
- 通过tNGS早期识别病原体可以指导有效的治疗并改善患者的治疗结果.
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