基于大麻的提取物用于治疗患有骨关节炎的狗的疼痛:疗效和安全性评估
Neide Maria Griebeler1, Ricardo Penayo Cremonese1, Yasmin Rafaela Fakih Correa1
1Laboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integração Latino Americana (UNILA), Foz do Iguaçu, Brazil.
Frontiers in pharmacology
|December 10, 2025
概括
全谱大麻提取物对患有骨关节炎 (OA) 的狗在90天内是安全的,尽管它没有显著降低疼痛评分. 需要进一步的研究,以获得最佳的狗OA疼痛管理.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 狗骨关节炎 (OA) 是一种常见的退行性关节疾病,会影响老犬的运动能力并引起疼痛.
- 目前的OA治疗方法在有效性和潜在的不良影响方面存在局限性.
- 大麻素显示出作为替代治疗犬OA的承诺.
研究的目的:
- 评估全谱大麻提取物的安全性和有效性,用于管理与OA相关的疼痛和狗的功能障碍.
- 评估提取物对狗OA患者疼痛水平和整体幸福感的影响.
主要方法:
- 一项为期90天的双盲随机研究,涉及17只患有OA的狗.
- 狗接受了全谱大麻提取物 (含CBD,THC,CBG,CBC) 或安慰剂.
- 使用赫尔辛基慢性疼痛指数 (HCPI) 评估疼痛.
主要成果:
- 大麻提取物是安全的,耐受性很好,没有报告显著的不良影响.
- 轻微的副作用是暂时的,自发消失.
- 观察到疼痛减轻的趋势 (比安慰剂低HCPI得分2.4分),但在统计学上没有显著意义.
结论:
- 含有CBD和THC的全谱大麻提取物在90天内对犬类使用是安全的.
- 需要进行进一步的研究,以确定最佳的剂量和配方,以有效地缓解狗的OA疼痛.
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