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氧化平衡得分与妇科癌症之间的关联使用NHANES 2011-2018数据

Yu' E Yang¹, Chunfang Ha²

¹The First Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750000 People's Republic of China.

International journal of women's health

|December 10, 2025

概括

较高的氧化平衡得分 (OBS),反映出更大的抗氧化剂摄入量,与降低患妇科癌症 (GC) 的风险有关. 保持良好的OBS可能有助于降低GC患病率.

科学领域:

在瘤学瘤学.
营养科学营养科学
流行病学流行病学

背景情况:

氧化应激是各种癌症发展的已知因素,包括妇科癌症 (GC).
氧化平衡与GC风险之间的关系需要进一步研究.

研究的目的:

评估氧化平衡得分 (OBS) 与妇科癌症 (GC) 的流行率之间的关联.
为此评估,利用国家健康和营养检查调查 (NHANES) 的数据.

主要方法:

从2011-2018年NHANES中分析了7816名成年女性的数据,其中195名被诊断患有GC.
基于20种饮食和生活方式成分的OBS计算 (15种抗氧化剂,5种亲氧化剂).
应用多变量逻辑回归来确定几率比率 (ORs) 和95%置信区间 (CI) 的GC在OBS tertiles.

主要成果:

较高的OBS总量与较低的GC几率显著相关 (调整的OR每单位增加=0.92;95%CI:0.86-0.97).
在最高的OBS三位数中,与最低三位数的人相比,OBS三位数中的人患GC的几率降低了34%.
OBS和GC之间的反向关联在60岁以上的女性,非吸烟者和正常BMI的女性中更为明显.

结论:

增加的抗氧化剂暴露,由更高的OBS表明,与妇科癌症风险相反相关.
研究结果表明,专注于改善饮食和生活习惯以提高氧化平衡的干预措施可以在降低GC风险方面发挥作用.

关键词:

抗氧化剂抗氧化剂是一种抗氧化剂.饮食饮食饮食饮食妇科新生病的新生病.生活方式生活方式氧化应激是一种氧化应激.

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