关于在绝经后患有骨关节炎和骨质疏松症的女性膝关节周围骨矿物质密度的研究
Zijian Guo1, Xingjia Mao2, Zehua Wang3
1Department of Orthopedic, The Second Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.
International journal of women's health
|December 10, 2025
概括
患有膝关节骨关节炎和骨质疏松症的绝经后妇女在膝关节周围的骨密度较低. 治疗骨质疏松症对于减少疼痛和可能减缓膝关节关节炎进展至关重要.
科学领域:
- 整形外科 整形外科 整形外科
- 类风湿病学 类风湿病学
- 老年学是指老年学的学科.
背景情况:
- 骨质疏松症 (OP) 和膝关节骨关节炎 (KOA) 经常在绝经后妇女中并存.
- 膝关节周围的OP和局部骨矿物质密度 (BMD) 之间的相互作用尚未得到充分理解.
研究的目的:
- 研究 KOA 的绝经后妇女同时 OP 对周关节 BMD 的影响.
- 为了检查周关节骨损伤,疼痛 (WOMAC),放射性严重程度 (K&L等级) 和对齐 (HKA角度) 之间的关联.
主要方法:
- 对117名患有KOA的绝经后妇女进行横截面研究,分为带有OP (n=59) 的KOA和仅KOA (n=58) 的KOA组.
- 双能X射线吸收计 (DXA) 用于OP诊断;双能计算断层扫描 (DECT) 用于周关节骨质量定量.
- 基尔格伦-劳伦斯 (K&L) 度和关节-膝关节 (HKA) 角度的负重放射;疼痛和功能评估的WOMAC问卷.
主要成果:
- 与单独KOA患者相比,KOA和OP患者表现出明显较低的膝关节BMD (P < 0.001).
- 在KOA与OP组中,即使对疼痛水平进行调整 (P <0.05),骨质量下降仍然存在 (P <0.05).
- 在KOA与OP组的KOA与OP组中,中间膝关节的BMD显示了与K&L等级的反转U形关系,与KOA单独组中看到的渐进增长不同. 在KOA与OP组中,在HKA角度和中间膝关节BMD之间发现了显著的反向相关性.
结论:
- 绝经后患有KOA和OP的女性显著减少了关节周 BMD.
- 较低的BMD与增加的疼痛,明显的放射特征和较差的膝盖对齐有关.
- 积极的骨保存和OP管理对于KOA患者来说至关重要,以缓解症状并可能减轻疾病进展.
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