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Updated: Jan 9, 2026

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
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Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

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通过促进线粒体裂变,Pyruvate Kinase Isoform 2的S-化驱动心脏纤维化

Shanshan Luo1,2,3, Danyu Ye1,2,3, Yan Zhang1,2,3

  • 1Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.).

Circulation
|December 10, 2025
PubMed
概括

心脏纤维细胞中pyruvate kinase M2 (SNO-PKM2) 的S- 化通过引起线粒体功能障碍导致心脏纤维化. 药物mitapivat激活PKM2,为心脏纤维化提供潜在的治疗策略.

关键词:
人类PKM2蛋白纤维化这样就好了线粒体

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