用于植入器骨整合的免疫调节生物材料:知识映射 (2005-2025)
Yue Li1,2, Geng Liu1,2, Chunxia Chen1,2
1Department of Prosthodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.
Tissue engineering. Part C, Methods
|December 10, 2025
概括
图书统计分析揭示了用于植入物骨整合的免疫调节生物材料的趋势. 最近的研究重点是用于临床翻译的3D打印和巨细胞极化.
科学领域:
- 生物材料科学 生物材料科学
- 免疫学 免疫学 免疫学
- 整形外科手术 整形外科手术
背景情况:
- 植入物骨整合对于骨科成功至关重要.
- 免疫调节生物材料提供了一个有前途的策略来增强这一过程.
- 需要对研究环境有全面的了解.
研究的目的:
- 从2005年到2025年,绘制出用于植入物骨整合的免疫调节生物材料的研究格局.
- 确定时间趋势,关键贡献者和新兴热点.
- 分析协作,期刊导向和翻译瓶.
主要方法:
- 来自Web of Science核心集合的出版物的图书统计分析.
- 识别时间趋势,贡献的国家,机构和期刊.
- 协作网络和关键词演变的分析.
主要成果:
- 确定了419篇文章,产量和引用量稳步增加.
- 中国,美国和澳大利亚是主要的贡献者.
- "3D打印"",支架"和"巨分化"是最近的热点,表明向临床翻译的转变.
结论:
- 该领域已经从骨质免疫调节理论发展到纳米工程和动态响应设计.
- 未来的研究应该专注于智能响应生物材料和多组学验证.
- 加快从被动修复转向骨再生中的积极调节是关键.
相关概念视频
01:25Immune Surveillance by NK Cells and Phagocytes
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
01:29Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.