遗传性视网膜疾病的干细胞治疗:从2000年到2024年的趋势和见解
Jinyi Long1, Ziyang Xu2, Ping Hu3
1Department of ophthalmology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cell transplantation
|December 10, 2025
概括
干细胞疗法在遗传性视网膜疾病 (IRDs) 中表现有前途. 研究正在从基础研究向临床试验推进,重点是细胞移植和有机体替代以恢复视力.
科学领域:
- 眼科医生 眼科 眼科
- 再生医学是一种再生医学.
- 生物医学研究生物医学研究
背景情况:
- 遗传性视网膜疾病 (IRD) 是导致视力丧失的重要原因之一.
- 干细胞治疗为IRD提供了潜在的治疗途径.
- 在这个领域缺乏对全球研究环境的系统分析.
研究的目的:
- 从2000年到2024年为IRDs绘制干细胞治疗的全球研究轨迹.
- 确定主要贡献者,出版趋势和主题演变.
- 为了澄清从基础研究向临床应用的过渡.
主要方法:
- 从科学网络核心收藏中对1060篇出版物的图书法分析.
- 使用CiteSpace和VOSviewer进行数据分析.
- 进行了关键词和共同引用分析.
主要成果:
- 观察到年度出版物的持续增加.
- 美国和中国在研究成果方面是领先的国家.
- 研究主题从视网膜色素表皮移植到器官替代和早期临床翻译.
结论:
- 针对IRD的干细胞治疗领域正在向临床应用迈进.
- 关键的挑战包括移植的生存,功能整合和免疫兼容性.
- 跨学科的合作对于加速临床进步至关重要.
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