表观遗传衰老时钟和发生的心血管结果:MESA的结果
Shantanu Srivatsa1,2, Noah Rice1, James R Pike2
1UNC Chapel Hill School of Medicine Gillings School of Public Health Chapel Hill NC.
Journal of the American Heart Association
|December 10, 2025
概括
像GrimAge这样的表观遗传衰老钟可以预测心血管疾病风险,包括心肌梗塞,特别是与冠状动脉 (CAC) 测量相结合时. 这些时钟提供了超越传统风险因素的宝贵见解.
科学领域:
- 心血管疾病研究研究
- 表观遗传学和衰老的研究
- 生物标志物发现发现
背景情况:
- 基于DNA甲基化的衰老时钟评估生物年龄,并可能提高心血管风险预测.
- 有限的数据存在于表观遗传时钟,事件心血管结果,以及它们与冠状动脉 (CAC) 等生物标志物的相互作用.
研究的目的:
- 研究表观遗传衰老时钟 (GrimAge,年龄加速) 与发生心血管疾病的结果之间的关联.
- 检查表观遗传衰老时钟与冠状动脉 (CAC) 在预测心血管风险方面的相互作用.
主要方法:
- 对1264名多民族动脉样硬化研究 (MESA) 参与者的回顾性队列研究.
- 从DNA甲基化数据评估了GrimAge和年龄加速.
- 利用考克斯的比例危险模型,对混因素进行调整,并按CAC存在进行分层,以分析与心血管事件的关联.
主要成果:
- GrimAge独立预测了复合心血管疾病,中风和心力衰竭的风险更高,喷射分数略有减少.
- 在CAC>0的个体中,与心肌梗塞风险的关联是显著的,但在没有基线CAC的人中减弱.
结论:
- 表观遗传衰老时钟可能会提供超越传统因素的心血管风险信息,并与CAC等亚临床疾病标志物相互作用.
- 需要对不同种群进行进一步的研究来验证这些发现,并探索针对表观遗传衰老或CAC的潜在干预措施.
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