内微生物群和癌症免疫:从致病源到通过人工智能治疗机会
Ivanna Honcharyuk1, Bruna Caridi2, Paola Pinco3
1Gastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Expert review of clinical immunology
|December 10, 2025
概括
内微生物组会影响癌症的发展和治疗. 了解微生物的作用和利用先进的人工智能技术可以个性化瘤学,以获得更好的患者结果.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 瘤内微生物组,包括细菌,真菌和病毒,显著影响瘤微环境.
- 它在瘤发生,免疫调节和对免疫检查点抑制剂等疗法的反应中发挥着关键作用.
- 微生物透甚至发生在无菌的器官瘤中,如大脑和乳腺癌.
研究的目的:
- 审查内微生物群和整个致癌过程中的免疫系统之间的复杂相互作用.
- 检查微生物代谢物,免疫逃避机制和传播途径.
- 概述瘤微生物组表征的当前和新兴技术.
主要方法:
- 在PubMed,Embase和Google Scholar的综合文献搜索 (2024年12月 - 2025年10月).
- 对专注于微生物代谢物,免疫劫持和传播的研究进行分析.
- 包括下一代测序,空间转录和人工智能 (AI) 在内的技术概述.
主要成果:
- 内微生物群影响瘤发生,免疫反应和治疗疗效.
- 像人工智能,机器学习和深度学习这样的先进技术对于诊断和预测治疗反应至关重要.
- 微生物的空间定位和功能特征是开发生物标志物和干预措施的关键.
结论:
- 将人工智能与空间和多学科数据集成为精密瘤学提供了重大机会.
- 挑战包括数据异质性,模型可解释性和道德考虑.
- 标准化的协议,高分辨率的空间分析和验证的数据集对于微生物组信息精确瘤学至关重要.
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