白俄罗斯子宫体恶性瘤的流行病学趋势:30年分析 (1993-2022)
Olga P Matylevich1,2, Sviatlana Y Shelkovich2, Alena G Balshakova1
1Gynecologic Oncology Division, N.N. Alexandrov National Cancer Centre of Belarus, Мinsk, Belarus.
概括
子宫体恶性瘤 (UCMs) 在白俄罗斯显著增加,特别是在年轻女性中. 尽管由于早期检测和治疗改善了生存率,但对节育选择和量身定制治疗的进一步研究至关重要.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 子宫体恶性瘤 (UCMs) 是一个严重的健康问题,白俄罗斯的发病率明显高于美国.
- 大部分UCM病例发生在生育年龄的妇女身上,这带来了独特的临床和管理挑战.
研究的目的:
- 检查白俄罗斯子宫体恶性瘤 (UCM) 的30年趋势.
- 分析发病率,死亡率和存活率,重点关注生育年龄妇女.
- 识别导致UCM趋势的因素,并为未来的管理策略提供信息.
主要方法:
- 分析了来自白俄罗斯癌症登记 (1993-2022) 的基于人口的数据.
- 国际疾病分类,第十次修订 (ICD-10) 代码C54-C55被用于识别UCM病例.
- 统计分析包括年龄标准化发病率和死亡率,5年相对存活率估计和趋势评估.
主要成果:
- UCM病例增加了2.7倍,年龄标准化发病率上升了122.1% (+0.001).
- 生殖年龄妇女的发病率增加了128.8% (p<0.001),特别是在35-49岁的妇女中.
- 早期诊断得到改善,5年相对存活率显著增加,在15-34岁年龄组达到100%.
结论:
- 白俄罗斯的UCM发病率显著增加,特别是在年轻女性中,可能是由于肥胖和环境暴露等非人口因素.
- 改进的早期检测和治疗提高了生存率,特别是在生育年龄的妇女中.
- 未满足的需求包括年轻患者的节育方法和老年妇女的量身定制疗法,强调需要持续监测和政策调整.
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