慢性鼻炎与鼻的生物疗法:病例分析和资格计划的建议
Grażyna Stryjewska-Makuch1, Maria Humeniuk-Arasiewicz1, Marcelina Niemiec-Urbańczyk1
1Department of Laryngology and Laryngological Oncology, Leszek Giec Upper-Silesian Medical Centre of the Medical University of Silesia, Katowice, Poland.
Otolaryngologia polska = The Polish otolaryngology
|December 10, 2025
概括
选择用于患有鼻息肉的慢性鼻炎 (CRSwNP) 的生物药物需要考虑生物标志物,喘控制和患者因素. 这项研究为选择有效的生物药物,如dupilumab或mepolizumab提供了指导.
科学领域:
- 免疫学和过敏学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 带鼻息肉的原发性慢性鼻炎 (CRSwNP) 是一种由2型 (T2) 炎症驱动的严重疾病.
- 针对T2炎症的生物疗法,如dupilumab和mepolizumab,已被批准用于CRSwNP治疗.
研究的目的:
- 提出作者指导的建议,以选择适合CRSwNP的生物剂.
- 根据临床经验和现有的关于CRSwNP生物治疗的文献提出建议.
主要方法:
- 根据EPOS指导方针和药物计划标准,CRSwNP患者有资格接受生物治疗.
- 生物选择考虑了病史 (控制喘,过敏,NSAID加剧的呼吸道疾病),总IgE和血液中乙烯基蛋白细胞数量.
- 包括对43名患者的分析:23名患者接受了美波利祖马布治疗,20名患者接受了dupilumab治疗.
主要成果:
- 在人口统计和基线临床/生物标志物数据方面,患者组相似.
- 在梅波利祖马布治疗组中,基线乙氨基酸细胞数量较高.
- 杜皮卢马布组显示过渡性乙酸细胞增加至3500细胞/μl,没有不良事件.
结论:
- 对CRSwNP的生物选择应将生物标志物数据与喘控制,口服皮质类固醇剂量,患者年龄和治疗方便性进行整合.
- 这些因素有助于优化CRSwNP患者的治疗结果.
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