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结肠直肠手术外科抗微生物预防的持续时间对并发症和抗体的影响
Louise L Southwood1, Alicia Long1, Jairo Perez1
1Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett, Pennsylvania, USA.
Equine veterinary journal
|December 10, 2025
概括
对于经过手术的马,建议进行24小时的手术抗菌预防 (SAP). 将SAP延长到72小时并没有改善临床结果,并且增加了肠道微生物群中的抗菌素耐药性基因.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 马类手术 马类手术
- 微生物组研究 微生物组研究
背景情况:
- 手术抗微生物预防 (SAP) 持续时间受到争议,人类研究表明>24小时是不必要的.
- 扩展的SAP可能会产生有害影响,包括发展抗菌素耐药性.
研究的目的:
- 为了比较24小时与72小时SAP接受手术的马匹的临床和微生物学结果.
- 评估SAP持续时间对马肠道微生物群和抗体的影响.
主要方法:
- 潜在的随机临床试验,涉及从结肠病手术中恢复过来的马.
- 马匹接受了24小时或72小时的SAP与青素和 gentamicin.
- 枪支元基因组测序分析了便样本,以表征微生物组和抗体变化.
主要成果:
- 在24小时和72小时SAP组之间,包括切口感染在内的临床并发症没有显著差异.
- 肠道微生物群的多样性下降,抗菌素耐药性基因从入院到出院在两个组增加.
- 在72小时的SAP组中观察到显著更高的β-乳抗性基因.
结论:
- 建议24小时的SAP用于接受直肠手术的马.
- 延长SAP (72小时) 没有临床益处,并且与抗菌素耐药性增加有关.
- 需要进行进一步的研究,承认诸如单中心研究和小数量的并发症等局限性.
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