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对于冠状动脉血液动力学1D-3D模拟的合策略的比较

P L J Hilhorst¹, A J E Vermeer^1,2, K Zając³

¹Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.

International journal for numerical methods in biomedical engineering

|December 10, 2025

概括

使用结合的1D-3D模型非侵入性地预测冠心断片流量储备 (FFR) 是可行的. 稳态3D模拟方法提供了最有效的计算方法,用于在冠状动脉狭窄时准确预测FFR.

科学领域:

心血管生理学心血管生理学
医疗成像医学成像
计算流体动力学的流体动力学.

背景情况:

使用计算建模的非侵入性分量流量储备 (FFR) 预测是侵入性方法的一个有希望的替代方案.
模拟冠状动脉狭窄是具有挑战性的,因为复杂的损伤几何和边界条件.

研究的目的:

评估结合的1D-3D建模策略,以在合成冠状动脉狭窄几何学中进行非侵入性FFR预测.
为了比较稳定状态与瞬态3D计算流体动力学 (CFD) 模拟的效率和准确性.

主要方法:

结合了全球1D流通模型与本地化的3D CFD模拟.
生成合成冠状动脉狭窄的几何形状 (对称,偏心,不规则) 在不同的严重程度.
通过平均流动驱动的稳定状态3D CFD与持续或周期结束时交换数据的短暂3D CFD进行比较.

主要成果:

所有测试的合策略都为合成狭窄几何体提供了类似的FFR预测.
稳态3D模拟策略显著降低了计算成本,并被证明是最有效的.
局部化的3D建模突出了与块状模型相比,不规则的病变压力损失的差异.

结论:

结合的1D-3D建模为非侵入性FFR预测提供了一种可行的方法.
稳态3D CFD是FFR预测中计算效率最高的策略.
高准确度的3D模拟对于准确评估复杂冠状动脉病变中的压力损失是有价值的.

关键词:

计算流体动力学的流体动力学.冠状动脉血液动力学针对患者的特定建模.脉冲波传播模型的脉冲波传播模型.减少订单建模的减少订单建模.

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