在流行病期间保护怀孕:最近的疫情告诉我们什么
Annette K Regan1,2, Flor M Muñoz3
1Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
Human vaccines & immunotherapeutics
|December 10, 2025
概括
最近的公共卫生紧急情况,如H1N1流行病和mopox爆发,突出了需要更好的疫苗和治疗安全评估在孕妇. 在怀孕期间提高疫苗接种率对于保护母亲和婴儿健康至关重要.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 围产儿医学 围产儿医学
背景情况:
- 公共卫生紧急情况不成比例地影响孕妇,增加他们患重病的风险.
- 过去的紧急情况,包括2009年流感A/H1N1大流行和最近的mopox疫情,已经产生了有价值的围产期药监数据.
- 从历史上看,孕妇被排除在疫苗和治疗药物的临床试验之外,限制了安全数据.
研究的目的:
- 审查最近关于孕妇的公共卫生紧急情况的见解.
- 评估包括孕妇在医学对策临床试验中的不断变化的情况.
- 确定在卫生危机期间改善疫苗接种和护理的挑战和机会.
主要方法:
- 作者根据最近公共卫生紧急情况的经验提供了评论.
- 对孕妇群体的临床试验纳入趋势的分析.
- 疫情期间对药监数据和疫苗接种策略的审查.
主要成果:
- 围产期药物监测能力有所提高,提高了对孕妇的授权后安全评估.
- 越来越多的趋势是将孕妇纳入临床试验.
- 在紧急情况下,医疗保健系统的压力会破坏重要的产前,分娩和产后护理.
结论:
- 在怀孕期间接种疫苗是可行的,但往往具有低于最佳的吸收率.
- 需要进一步的研究,以了解和解决怀孕人口的疫苗犹.
- 将孕妇健康考虑因素纳入流行病准备是保护孕妇和新生儿的关键.
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