查和管理与代谢功能障碍相关的脂肪性肝病 (MASLD)
1Anne Geary is an assistant professor at Butler University in Indianapolis, IN, and a PA at Hendricks Regional Health in Danville, IN. The author has disclosed no potential conflicts of interest, financial or otherwise.
JAAPA : official journal of the American Academy of Physician Assistants
|December 10, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球30%的人口,与代谢综合征有关. 本综述更新了初级保健医生协会对MASLD检测,非侵入性测试以及像resmetirom这样的新疗法.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 初级医疗保健医学 一级医疗保健医学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,是影响30%人口的全球健康问题.
- MASLD与代谢综合征,胰岛素耐药性和心血管疾病密切相关.
- 初级保健提供者,包括医生助理 (PA),对于早期MASLD检测和管理至关重要.
研究的目的:
- 为初级保健医生提供关于MASLD的最新概述.
- 专注于疾病病理生理学,风险分层,查和管理策略.
- 引导PAs使用新的药理疗法和非侵入性诊断工具.
主要方法:
- 关于MASLD病理生理学,诊断和治疗的当前文献的综述.
- 强调非侵入性测试方法,如FIB-4和肝硬度测量.
- 讨论生活方式干预作为一线治疗和药理选择.
主要成果:
- 建议进行非侵入性测试,用于MASLD的诊断和监测.
- 雷斯米蒂罗姆是FDA批准的第一个药物治疗方法,用于治疗中度至晚期纤维化症的非循环性MASH.
- AASLD的指导方针支持在没有肝脏活检的情况下使用resmetirom,而semaglutide是新兴的选择.
结论:
- 初级保健医疗机构需要最新的知识来有效管理MASLD.
- 非侵入性诊断和生活方式干预是MASLD护理的关键组成部分.
- 像resmetirom这样的新药学治疗方法为MASH患者提供了改善的结果.
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