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在尼日利亚的常规环境中,使用Truenat平台在儿童中诊断结核病的便测试的评估
J O Olabamiji1, K Ochei2, O Daniel1
1Institute of Human Virology Nigeria, International Research Centre of Excellence (IRCE), BAZE University, Abuja, Nigeria.
Journal of clinical microbiology
|December 10, 2025
概括
特鲁纳特平台准确检测儿童的结核病 (TB).
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 世界卫生组织建议用于儿童结核病 (TB) 诊断的便检测.
- 优选的初始诊断测试是Xpert MTB/RIF Ultra (Xpert-Ultra) 的初始诊断测试.
- 特鲁纳特平台为缺乏GeneXpert的偏远地区提供了潜在的替代方案.
研究的目的:
- 在尼日利亚的Truenat平台上验证便处理和测试协议.
- 为了比较Truenat MTB Plus (Truenat) 与Xpert-Ultra用于儿童结核病检测的性能.
主要方法:
- 在尼日利亚进行了一项比较的横截面研究.
- 来自510名可能患有结核病的儿童的便样本在Truenat和Xpert-Ultra上进行了测试.
- 适应的简单的一步 (SOS) 便方法用于Truenat加工.
主要成果:
- 在Truenat和Xpert-Ultra之间观察到很高的一致性 (95.8%).
- 使用100毫克的便,Truenat准确检测出Mycobacterium结核病 (MTB).
- 与Xpert-Ultra (1.2%) 相比,Truenat显示了较高的未确定结果率 (4.7%).
结论:
- 适应Truenat的SOS便协议在常规环境中有效检测MTB.
- 特鲁纳特有望在资源有限的偏远地区扩大儿童结核病诊断.
- 优化提取方法是必要的,以减少非确定的结果,并改善案例的发现.
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