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Updated: Jan 9, 2026

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

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HLA-C*14:171,一个具有罕见细胞外α3域的新等位基因

Mirzokhid Rakhmanov1, Martin Bernheiden1, Murielle Verboom2

  • 1Institute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Medical Faculty - University of Freiburg, University of Freiburg, Freiburg, Germany.

HLA
|December 10, 2025
PubMed
概括

一个新的人类白细胞抗原C等位基因,HLA-C*14:171,已被确定. 它因单个核酸替代而与已知的HLA-C*14:02:01:01等位基因不同.

关键词:
在HLA-C*14:171中.哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈没有NGS,没有NGS.细胞外的α3域一个新型的等位基因

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Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
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