长期COVID中慢性炎症和改变的免疫反应与神经症状和加速衰老有关
Norina Tang1, Judith M Ford2, Kaitlyn Dal Bon2
1Department of Laboratory Medicine, San Francisco VA Health Care System, San Francisco, CA 94121, USA.
Cells
|December 10, 2025
概括
长期COVID的神经症状与持续的炎症和高血蛋白有关,即使在SARS-CoV-2感染数年后也是如此. 这些生物标志物可能表明加速衰老,并有助于诊断nLongC.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 遗传学 遗传学 是一个
背景情况:
- 一组感染SARS-CoV-2的个体经历了持续的神经症状 (nLongC).
- 导致nLongC和长期COVID-19后遗症的潜在生物机制尚不完全理解.
研究的目的:
- 调查持续性炎症标志物和与SARS-CoV-2感染后神经系统连续症相关的遗传因素.
- 确定潜在的生物标志物,以诊断和理解nLongC.的病理生理学.
主要方法:
- 在康复的COVID-19 (Cov) 个体中比较血蛋白水平和阿波利波蛋白E4 (APOE4) 基因载体,那些患有nLongC的人,和健康的对照 (HC).
- 分析了特定炎症标志物的纵向变化.
- 利用多种生物标志物模型,包括血蛋白,年龄,BMI和APOE4状态来评估诊断潜力.
主要成果:
- 与康复个体相比,患有nLongC的个体具有更高的APOE4基因患病率.
- 在Cov和nLongC组与HC组相比,四种血蛋白 (IL-1β,IL-8,GFAP,血素) 在Cov和nLongC组都升高.
- 在两组患者中,高IL-8和GFAP与年龄相关.
- 生物标志物的组合模型实现了区分组的AUC为0.81.
结论:
- 感染SARS-CoV-2可能会导致慢性,低级炎症状态,在急性疾病后持续很长时间.
- 持续性炎症和特定的生物标志物与nLongC相关,可能导致加速衰老.
- 已识别的生物标志物显示出有助于诊断和理解COVID-19长期神经效应的潜力.
更多相关视频
07:58Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
Published on: April 16, 2012
35.4K
09:35Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
10.5K
相关概念视频
01:26Aging
566
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
566
01:19Psychoneuroimmunology: Diabetes and Cancer
409
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
409
01:27Psychoneuroimmunology: Cardiovascular Disease
367
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
367
01:30Stress and Mental Health
564
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
564
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.2K
01:24Chronic Pancreatitis I: Introduction
645
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
645