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食道腺癌及其瘤微环境之间的相互作用:朝着创新疗法发展

Rodanthi Fioretzaki¹, Eleni-Myrto Trifylli², Panagiotis Sarantis^2,3,4

¹First Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, 11527 Athens, Greece.

|December 10, 2025

概括

食道癌 (EC) 是一个日益严重的全球健康问题. 这篇评论探讨了瘤微环境.

科学领域:

胃肠道学和瘤学
癌症生物学癌症生物学
免疫治疗是一种免疫疗法.

背景情况:

全球食道癌 (EC) 发病率正在上升,对健康造成重大负担.
关键的亚型包括食道腺癌 (EAC) 和食道状细胞癌 (ESCC).
EAC与胃食道逆流性疾病,巴雷特食道和肥胖有关,特别是在西方人群中.

研究的目的:

审查瘤微环境 (TME) 在EAC进展中的作用.
讨论TME对EAC耐药性的影响.
为了突出食道癌症治疗的近期治疗进展.

主要方法:

文献综述专注于食道腺癌中的瘤微环境.
对EAC进展和药物耐药性机制的研究分析.
综合当前关于免疫疗法和其他治疗策略的研究.

主要成果:

瘤微环境显著影响EAC的进展和治疗反应.
了解TME与癌细胞的相互作用对于克服耐药性至关重要.
免疫疗法是食道癌治疗的有前途的研究领域.

结论:

瘤微环境是食道腺癌的一个关键因素.
针对TME提供了改善治疗策略的潜力.
对TME动态和免疫治疗的进一步研究对于推进EC护理至关重要.

关键词:

消化道腺癌 (adenocarcinoma) 的发生这是食道癌的癌症.的胃肠道瘤.免疫疗法免疫疗法瘤微环境是一个微环境.

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