梅尔斯-CoV RBD-mRNA 呈现出比 Spike-mRNA 更好的免疫性和保护性
Qian Liu1, Abhishek K Verma2, Xiaoqing Guan1
1Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Cells
|December 10, 2025
概括
与小鼠的spike (S) mRNA疫苗相比,受体结合域 (RBD) mRNA疫苗表现出优越的免疫性和对中东呼吸综合征冠状病毒 (MERS-CoV) 的保护.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 疫苗开发 疫苗开发
背景情况:
- 中东呼吸综合征冠状病毒 (MERS-CoV) 构成重大公共卫生风险.
- MERS-CoV尖端 (S) 蛋白质,特别是它的受体结合域 (RBD),对于病毒进入至关重要,也是疫苗开发的关键目标.
- 缺乏S-vs-RBD基MERS-CoV疫苗的免疫性和疗效的直接比较研究.
研究的目的:
- 为了比较两个针对MERS-CoV的S蛋白 (S-mRNA) 或RBD (RBD-mRNA) 的mRNA疫苗的免疫性,中和活性和保护功效.
- 在小鼠模型中评估免疫反应的持久性和这些疫苗所赋予的保护.
主要方法:
- 两种脂质纳米粒子 (LNP) 封装的mRNA疫苗S-mRNA和RBD-mRNA被开发并给小鼠使用.
- 通过测量抗体标位和对MERS-CoV菌株和变种的中和活性来评估免疫性.
- 在中年老鼠模型中评估了保护疗效,该模型受到MERS-CoV的挑战.
主要成果:
- 这两种LNP封装的mRNA疫苗在各种温度下都表现出稳定性.
- 与S-mRNA相比,RBD-mRNA引起了显著更高和更持久的抗体反应.
- RBD-mRNA对MERS-CoV及其变体表现出更强大和更广泛的中和活性,并为小鼠提供了对感染的持久保护.
结论:
- 与LNP封装的RBD-mRNA是一种高效的针对MERS-CoV的候选疫苗.
- 由于其优越的免疫性,中和能力和保护功效,RBD-mRNA疫苗显示出进一步开发的巨大潜力.
更多相关视频
相关概念视频
Rous Sarcoma Virus (RSV) and Cancer
6.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.1K
Immune Response Against Viral Pathogens
1.6K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.6K
Recombinant DNA
101.5K
Overview
101.5K
Rab Proteins
4.9K
Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
4.9K
Cell-mediated Immune Responses
83.3K
Overview
83.3K
Immunological Memory
14.9K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
14.9K


