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系统性硬化症胃肠道参与中的细胞参与者:对病变发生的洞察
Silvia Peretti1, Francesco Bonomi1, Giulia Bandini1
1Department of Internal Medicine, University Hospital Careggi, 50134 Florence, Italy.
Cells
|December 10, 2025
概括
系统性硬化 (SSc) 中的胃肠道问题涉及纤维化前的神经肌肉变化. 了解这些复杂的细胞机制是开发超越症状管理的向治疗的关键.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 胃肠道 (GI) 干扰是系统性硬化症 (SSc) 最常见的内脏并发症,影响高达90%的患者.
- 在SSc中胃肠道表现的理解比肺部或皮肤并发症要少.
- 当前的理解往往遵循"纤维化第一"的范式,这可能是不完整的.
研究的目的:
- 审查和整合有关SSc.肠道疾病细胞机制的当前知识.
- 确定SSc相关的胃肠道并发症的研究优先事项.
主要方法:
- 进行了叙事文学评论.
- 系统的PubMed搜索到2025年9月,辅以手动参考选.
主要成果:
- 有证据表明神经肌肉变化 (肠神经元退化,Cajal间歇细胞丧失,光滑肌肉缩) 可能是纤维化之前的.
- 纤维细胞和肌纤维细胞的激活发生,由TGF-β.等益纤维细胞介质维持.
- 其他因素包括自主功能障碍,障碍物功能障碍与失能症,肠道血管储备受损和自身抗体.
- 消化道的纤维化和炎症比皮肤/肺部少,这表明免疫病原性途径明显.
结论:
- 胃肠道参与SSc是一个多部件的过程,涉及神经,上皮,内皮,脑膜和免疫变化.
- 缺乏经过验证的生物标志物,机械模型和生物标志物分层试验阻碍了进展.
- 未来的研究应该集中在SSc相关的胃肠道疾病的精准医学方法上.
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