在临床获得的MRI数据集中定义的童年和青春期额外轴性脑脊液的规范轨迹
Ayan S Mandal1,2,3, Lena Dorfschmidt2,3, Jenna M Schabdach2,3
1Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104.
Radiology. Artificial intelligence
|December 10, 2025
概括
额外轴性脑脊液 (eaCSF) 的新生长图有助于诊断脑下空间良性扩大 (BESS). 这些图表提供了与年龄相关的基准,用于评估儿童不典型的eaCSF发育.
科学领域:
- 神经辐射学神经辐射学
- 儿科成像学 儿科成像学
- 量化MRI是指数量化的MRI.
背景情况:
- 脑下空间良性扩大 (BESS) 需要准确的诊断标准.
- 外轴脑脊液 (eaCSF) 的体积随着年龄的增长而动态变化.
- 建立eaCSF的规范性数据对于识别异常发展至关重要.
研究的目的:
- 开发儿童额外轴性脑脊液 (eaCSF) 容量的规范性生长图表.
- 通过使用与年龄相关的eaCSF基准来定义下大脑下空间良性扩大 (BESS) 的诊断标准.
- 帮助评估不典型的脑脊液发育.
主要方法:
- 从1205名儿科患者 (0.19-19.6岁) 的T1加权MRI扫描进行了回顾性分析.
- T1w扫描的细分以量化eaCSF体积.
- 使用位置,规模和形状 (GAMLSS) 的通用添加模型对eaCSF生长图的建模.
主要成果:
- eaCSF体积表现出随着年龄的增长而发生的动态变化,从出生到2岁时减少,然后增加.
- 在被诊断患有BESS的9名患者中,有7名患者的eaCSF测量高于97.5百分点.
- 开发的百分点得分有效地将BESS患者与对照患者区分开来 (AUC > 0.95).
结论:
- 来自MRI的eaCSF测量显示了生命早期与年龄相关的动态进化.
- 当eaCSF的计算测量与规范建模相结合时,可以将非典型的CSF发育与对照区分开来.
- 开发的eaCSF生长图表为诊断BESS提供了有价值的工具.
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