Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Local, but not circulating, complement C3 shapes immune checkpoint blockade efficacy by controlling myeloid cell infiltration.

Nature communications·2026
Same author

SATB1 preserves CD4<sup>+</sup> T-cell fidelity and establishes Treg function in antitumor immunity.

Life science alliance·2026
Same author

Branching of O-mannose glycans regulates node of Ranvier organization and saltatory conduction.

Communications biology·2026
Same author

Novel <i>GPRC5B</i>::<i>PRKCA</i> gene fusion in an unclassifiable low-grade glioneuronal tumor.

Neuro-oncology advances·2026
Same author

Anti-PD-1 plus anti-CTLA-4 blockade overcomes immune exclusion in NSCLC brain metastases by enhancing CD8<sup>+</sup> T cell responses and promoting tertiary lymphoid structure formation.

Nature communications·2026
Same author

Preoperative sarcopenia diagnosed based on the asian working group criteria and Short-term outcomes in older patients undergoing resection of early-stage non-small cell lung cancer.

Surgery today·2026

相关实验视频

Updated: Jun 14, 2026

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.6K

微质显示异质的初始反应传播的瘤细胞.

Takahiro Tsuji1, Haruka Hirose2, Daisuke Sugiyama3

  • 1Nagoya University, Japan.

Cancer research
|December 10, 2025
PubMed
概括

研究人员发现了称为微质的脑免疫细胞如何对早期脑转移进行反应. 调节这些微质细胞可能为消除瘤在扩散之前提供新的治疗策略.

更多相关视频

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

10.3K
Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination
04:53

Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination

Published on: April 5, 2022

4.1K

相关实验视频

Last Updated: Jun 14, 2026

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.6K
Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

10.3K
Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination
04:53

Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination

Published on: April 5, 2022

4.1K

科学领域:

  • 神经科学是一个神经科学.
  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.

背景情况:

  • 大脑转移是晚期癌症的常见和致命结果.
  • 微质细胞,大脑的免疫细胞,在成熟的瘤中具有复杂的作用,但它们的早期功能尚不清楚.
  • 了解早期的微质反应对于开发针对新生脑瘤的疗法至关重要.

研究的目的:

  • 在大脑转移的初始发展过程中研究微质群体的动态行为和异质性.
  • 在早期瘤微环境中确定调节微质表型的分子机制.
  • 探索针对微质细胞的治疗策略,以对抗大脑转移的早期干预.

主要方法:

  • 在体内命运映射和时间延迟成像来追踪瘤细胞和微质细胞.
  • 单细胞RNA测序以分析微质转录异质性.
  • 光电学 (全息照片转换) 用于精确的时空操纵.
  • 基因和药理干预来扰乱微质反应.

主要成果:

  • 微质表现出显著的转录和形态异质性,鉴定出明显的亲和抗瘤子组.
  • 抑制转化生长因子-β (TGF-β) 信号改变的微质表型.
  • 删除瘤细胞表面抗原CD24a和CD47调节的微质状态.
  • 早期的微质反应显示出可塑性,可以在治疗上准.

结论:

  • 微质异质性在脑转移的早期阶段起着至关重要的作用.
  • 准TGF-β信号或特定的瘤抗原可以将微质重编程到抗瘤状态.
  • 利用亲细胞微质功能为早期大脑转移干预提供了潜在的治疗窗口.