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Updated: Jan 9, 2026

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冷保存的动物疾病模型的质量框架:EMMA存档和分发中的INFRAFRONTIER质量原则

Hilke Ehlich1, Andrew Blease2, Reva Biju2

  • 1INFRAFRONTIER ERIC, Neuherberg, Germany. hilke.ehlich@infrafrontier.eu.

Mammalian genome : official journal of the International Mammalian Genome Society
|December 10, 2025
PubMed
概括

欧洲鼠标突变档案馆 (EMMA) 为冷保存的动物菌株制定了十项质量原则. 这些原则提高了研究生物资源的质量,透明度和可重复性.

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Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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