使用不同维生素D补充方案的循环25-基维生素D的动力学和度
Varta Babalyan1, Nicholas Hutchings2,3,4, Sisak Baghdasaryan1
1Osteoporosis Center of Armenia, Yerevan, Armenia.
概括
在亚美尼亚测试了三种维生素D补充策略. 所有方案都成功地在12周内将维生素D水平提高到足够的水平,这使得提供者在选择患者特定治疗计划时具有灵活性.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 营养科学 营养科学
背景情况:
- 维生素D缺乏是一个全球性的健康问题.
- 现有的维生素D替代指南在亚美尼亚缺乏测试.
- 这项研究解决了在亚美尼亚人口中基于证据的补充策略的需求.
研究的目的:
- 为了评估三种不同的维生素D剂量方案的疗效.
- 为了比较低剂量-高频率,中剂量-中频率和高剂量-低频率补充.
- 为亚美尼亚成年人确定最佳的维生素D补充策略.
主要方法:
- 在亚美尼亚埃里温社区居住的,患有维生素D缺乏症的成年人被招募.
- 参与者被随机分配到三个组,接受不同的口服维生素D剂量和频率12周,随后是维持剂量.
- 在基线和多次间隔至36周监测血清25(OH) D水平.
主要成果:
- 这三种维生素D补充方案都在8周内导致25...OH) D水平在统计学上显著增加.
- 维生素D水平在第8周达到40多岁中期的平原 ng/mL,并保持稳定.
- 在第36周,群体之间没有观察到25...OH) D水平的显著差异,除了A组与B组的轻微差异外.
结论:
- 不同的维生素D剂量方案在达到稳定状态时达到相似的理想水平.
- 医疗保健提供者可以根据个体患者的变量和偏好选择维生素D替代策略.
- 这些发现支持亚美尼亚维生素D补充方案的适应性.
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