帕金森病中骨折发生率和骨质疏松症治疗:基于人口的队列研究
Jamie L Fleet1,2,3, Brooke Carter4, Suzanne M Cadarette5,6,7
1Department of Physical Medicine and Rehabilitation, Schulich School of Medicine and Dentistry, Western University, London, Canada. Jamie.fleet@sjhc.london.on.ca.
概括
新被诊断患有帕金森病 (PD) 的个人面临高骨折风险,但骨质疏松症查和治疗水平较低. 积极的骨健康策略对于这一处于风险的人群至关重要.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 骨健康研究 骨健康研究
背景情况:
- 患有帕金森病 (PD) 的个人表现出较高的跌倒率和骨质疏松症,导致骨折的风险更高.
- 骨健康在PD患者中经常被忽视,尽管它具有临床意义.
- 这项研究解决了在新诊断的PD患者中了解骨折发生率和骨质疏松症管理方面的差距.
研究的目的:
- 为了确定新诊断患有帕金森病的个体的骨折率.
- 评估这一群体中骨质疏松症药物的使用情况.
- 评估新诊断的帕金森病患者骨矿物质密度 (BMD) 查的频率.
主要方法:
- 一项基于人口的队列研究利用了加拿大安大略省 (2008-2023) 的行政数据.
- 包括65岁以上新诊断患有帕金森病的人 (n=28,119).
- 在诊断后一年内分析骨折率,骨质疏松症药物处方和骨髓质量测试,并按性别分层并根据共变量进行调整.
主要成果:
- 在PD诊断一年内,3.1%的人经历了脆弱性骨折.
- 只有9.8%的人接受了骨质量测试,17.6%的人被处方骨质疏松症药物.
- 在女性中观察到较高的骨折率,即80岁以上的女性,先前有过脆弱性骨折,并具有较高的并发症评分.
结论:
- 尽管骨折风险较高,骨质疏松症查和治疗率在帕金森病诊断后的一年内仍然很低 (<20%).
- 这些发现强调了在帕金森病护理中迫切需要综合性骨健康管理策略.
- 积极的干预措施对于减轻帕金森病患者面临的重大骨折风险至关重要.
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