非编码RNA和cernas:在结直肠癌中药物反应的新兴调节器

Elahe Shams¹, Elahe Daskar Abkenar¹, Negin Sina¹

¹Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Molecular biology reports

|December 10, 2025

概括

结肠直肠癌的耐药性是一个重大挑战. 非编码RNA (ncRNA) 和竞争的内源RNA (ceRNA) 网络显著影响治疗的有效性,并为克服耐药性提供新的治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

结肠直肠癌 (CRC) 仍然是全球癌症发病率的主要原因.
药物耐药性显著损害了CRC的治疗疗效.
非编码RNAs (ncRNAs) 正在成为CRC中药物反应和耐药性的关键调节者.

研究的目的:

综合审查ncRNAs (miRNAs, lncRNAs, circRNAs) 在抵抗主要CRC抗癌剂中的作用.
探索竞争性内源RNA (ceRNA) 网络在CRC耐药性中的参与.
讨论针对ncRNA和ceRNA网络的新型治疗策略,以克服CRC中的耐药性.

主要方法:

对ncRNAs和CRC药物耐药性的现有文献进行系统审查.
对针对单个药物 (5-FU,oxaliplatin,cetuximab,bevacizumab,regorafenib) 和组合疗法 (例如,FOLFOX) 的特定ncRNAs (miRNAs,lncRNAs,circRNAs) 的研究分析.
审查关于ceRNA网络的研究,它们在药物敏感性/耐药性中的作用,以及临床试验结果.

主要成果:

特定的miRNAs,lncRNAs和circRNAs与对各种CRC化疗和向药物的耐药性密切相关.
ceRNA网络在调节CRC中药物敏感性和耐药性方面发挥着至关重要的作用.
临床证据支持ncRNA和ceRNA网络的向,以改善患者的治疗结果.

结论:

ncRNA和ceRNA网络是结直肠癌中耐药性的关键决定因素.
针对这些网络提供了一个有希望的治疗途径,以提高药物敏感性和克服CRC中的耐药性.
基于ncRNA的策略的进一步研究和临床应用有可能改善CRC治疗结果.

关键词:

在CeRNA网络中,结肠直肠癌是一种癌症.药物耐药性药物耐药性药物耐药性

相关概念视频

02:39

lncRNA - Long Non-coding RNAs

9.7K

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

9.7K

02:39

lncRNA - Long Non-coding RNAs

3.4K

01:31

Transducer Mechanism: Nuclear Receptors

2.3K

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:

2.3K

01:23

Types of RNA

72.4K

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

72.4K

01:29

Translational Regulation

497

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...

497

02:57

Targeted Cancer Therapies

8.6K

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

8.6K