在精神病学中实施精准医学
Federico Cevoli1, Husseini K Manji2,3,4, Andrew H Miller5
1Fondation FondaMental, Créteil, France.
JAMA psychiatry
|December 10, 2025
概括
对神经精神疾病的药物发现需要一个范式的转变. 精准精神病学,由生物标志物发现和改革的临床试验驱动,为心理健康状况提供更有效的治疗方法.
科学领域:
- 神经科学和精神病学 在
- 翻译医学是一种翻译医学.
背景情况:
- 神经精神疾病是全球健康的重大负担.
- 在过去的50年里,在开发基于机制的精神疾病治疗方法方面取得的进展有限.
- 现有的药物发现管道已经产生了很少的验证治疗方法.
研究的目的:
- 确定精神障碍药物发现进展缓慢的原因.
- 提出一个转向精确精神病学的范式转变.
- 为推进精神病药物开发提出建议.
主要方法:
- 审查精神病药物发现当前的挑战.
- 分析开发基于机制的治疗方法有限成功的原因.
- 讨论潜在的解决方案,包括生物标志物发现和临床试验改革.
主要成果:
- 确定了阻碍心理疾病有效药物发现的关键障碍.
- 建议过渡到精确精神病学,利用生物标志物进行向治疗.
- 倡导改革临床试验方法,包括基于生物标志物的适应性设计.
结论:
- 精准精神病学为开发神经精神疾病的新疗法提供了一个有前途的框架.
- 生物标志物发现和创新的临床试验设计对于加速进展至关重要.
- 增加投资和跨部门合作对于实现精准精神病学的潜力至关重要.
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