在休马拉松跑者中,心室功能的长期变化
Michael Johannes Schindler1,2, Julia Schoenfeld2,3, Amelie Trommler2
1University Center for Prevention and Sports Medicine, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
JAMA cardiology
|December 10, 2025
概括
重复的马拉松跑步并没有导致长期的右心室损伤,尽管有暂时的托罗邦素T增加. 在男性耐力运动员中,左心室功能变化在10年内保持在正常范围内.
科学领域:
- 心脏病学 心脏病学
- 运动医学 运动医学
- 运动生理学 运动生理学
背景情况:
- 艰苦运动对心脏功能,特别是右心室的长期影响尚未完全理解.
- 耐力赛后血中热素水平可能会增加,但其长期影响仍然不清楚.
研究的目的:
- 为了检查马拉松诱导的热素T升高和经过十年的持续耐力训练后右心室重塑之间的关联.
- 评估男性马拉松运动员右心室和左心室功能的长期变化.
主要方法:
- 一项纵向观察队列研究 (Pro-MagIC) 追踪了152名男子马拉松运动员10年.
- 心脏生物标志物和3D回声心脏成像在多个时间点进行测量:赛前,赛后立即,赛后1,3天和10年.
- 分析的重点是右心室喷射率,左心室喷射率和左心室填充压力.
主要成果:
- 马拉松后右心室喷射分数暂时下降,但在3天后恢复到基线水平,并在10年随访时保持稳定.
- 没有发现急性运动诱导的热素T增加和长期的右或左心室喷射小部分之间存在关联.
- 左心室喷射分数和透气功能显示出变化,但在10年随访时仍在正常的生理界限内.
结论:
- 在休男性运动员中,重复的艰苦运动和马拉松比赛似乎不会导致长期的右心室功能障碍.
- 虽然急性心脏生物标志物升高发生,但它们不能预测这种人群的长期不良心脏重塑.
- 耐力运动员保持心脏功能在正常范围内,尽管在十年内有大量的训练负载.
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