冷-EM揭示了多药物排放MdtB和MdtF的结构异质性和形状灵活性

Surekha Padmanaban1, Clayton Fernando Rencilin1, Rupam Biswas1,2

  • 1Molecular Biophysics Unit, Indian Institute of Science, Bengaluru, India.

mBio
|December 10, 2025
PubMed
概括

抗性结节细胞分裂 (RND) 排泄,如大肠杆菌中的MdtB和MdtF,是多药耐药性的关键. 冷EM揭示了新的结构和动态,为抗生素流出机制提供了洞察力.

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